Single-cell heterogeneity and dynamic evolution of Ph-like acute lymphoblastic leukemia patient with novel TPR-PDGFRB fusion gene
Abstract Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a refractory and recurrent subtype of B-cell ALL enriched with kinase-activating rearrangements.Incomplete understanding of the heterogeneity within the tumor cells presents a major challenge for the Charging Stand diagnosis and therapy of Ph-like ALL.Here, we exhib